Manchester United host Arsenal in a mouthwatering match at Old Trafford.
These sides met in May when a 0-0 draw was enough for United to claim their third straight title.
MANCHESTER UNITED TEAM NEWS
Rio Ferdinand and Edwin van der Sar remain United's major absentees for the big showdown.
Sir Alex Ferguson feels Ferdinand may not quite be ready for the trip to Tottenham Hotspur on 12th September but his recovery from a thigh injury will not keep him out for much longer.
Ben Foster will continue in goal, while Michael Carrick and Anderson are hoping for recalls after missing the five-goal rout of Wigan Athletic.
ARSENAL TEAM NEWS
Arsenal midfielder Cesc Fabregas has been ruled out of Saturday's Barclays Premier League match with Manchester United.
Fabregas has failed to recover from his hamstring injury in time for Old Trafford but the Gunners have no fresh injury concerns following Wednesday night's 3-1 victory over Celtic.
Theo Walcott (back), Lukasz Fabianski (knee), Samir Nasri (broken leg) and Johan Djourou (knee) all continue their rehabilitation.
Manchester United: Foster, Kuszczak, Neville, O'Shea, De Laet, Brown, Vidic, Evans, Evra, Fabio, Nani, Carrick, Scholes, Fletcher, Anderson, Giggs, Park, Tosic, Valencia, Owen, Rooney, Berbatov, Macheda.
Arsenal: Almunia, Sagna, Vermaelen, Gallas, Clichy, Song, Ramsey, Denilson, Diaby, Bendtner, Eduardo, Mannone, Van Persie, Eboue, Arshavin, Wilshere, Gibbs, Silvestre, Merida.